Saturday, May 18, 2013

Mary Buffett: Reflections of a Modern Thailand

When I was growing up, my parents encouraged me to travel globally because so much history happens outside of our borders. The great conflicts of the past century occurred not in Kansas or Illinois, but in faraway places like Europe and the Pacific.

While it's wonderful to get lost in those great European cities, it is even more exciting to see the new green shoots of opportunity emerge in South East Asia, a region that until the Cold War ended, remained a major flashpoint between East and West.

I recently returned from Thailand after being the keynote speaker at a special conference for Thai investors sponsored by Money Channel with Stock Exchange of Thailand (SET) and Bank of Ayudhya PLC. I presented the ideas, tactics and investment strategies of Warren Buffett.
I was struck by the thirst the Thai people had for financial knowledge. This was more than a typical American conversation about making a lot of money and spending it; the Thai conversation was focused on the long-term, something that they could pass along to their children.

I found Thailand to be a special place. Some Americans look at Thailand as an exotic travel destination or the setting for The King and I. I have traveled to many countries; Thailand had the most welcoming, generous, humble, enlightened people I have ever met. Then there's the food, there is purpose in everything they do, beauty in the simplest ways. Breathtaking flowers, the development of the silk trade, to say nothing of the majestic temples surrounding the palace -- and the skyline of one of the greatest cities in the world -- that still has a sense of history and modernity. The future of Thailand is an exciting and emerging business climate that will bring long-term stability and allow Thailand to leave its thumbprint on the region.

The political scene has calmed down after challenges of the past. The current leadership knows that political stability attracts foreign investment and economic success. Downtown Bangkok is undergoing a building boom and as I talked with the conference participants, I could see that Thailand is lining up to be the next financial powerhouse for banking and investing.

People underestimate the resilience of the Thai culture and its people. Unlike many nations in the region, Thailand retains its ancient royal legacy. While a constitutional monarch, King Rama IX has offered Thailand a guiding light of national continuity over the past 63 years, making him the globe's longest reigning sovereign, serving three more years than his more famous contemporary, Queen Elizabeth II. Like Great Britain, Rama IX has guided his nation through world wars, but unlike Elizabeth II, he has also guided his country through a number of military coups as well as political and economic instability. Surviving in a locale where many of his contemporaries were either seen as puppets or worse, his wisdom speaks volumes.

Through it all, both the King and Queen retain a special place in their people's hearts at home or abroad. The next time you dine on authentic Thai cuisine, look around and you'll find a picture of the royal couple, usually in a place of honor. Rama IX's great-great grandfather, Mongkut (Rama IV) often makes a cameo appearance in most high school World Civilization textbooks. During the great colonial land grabs by European nations at the end of the19th century, Thailand was the rare nation that retained its independence, as Mongkut played a careful game of pitting one European power against another. In fact, Mongkut is the "King" from "King and I."

During a more dangerous time, Thailand also served as the beacon of freedom as people fled the communist takeovers of their native lands. With leaky boats motoring from Vietnam or those who took to the jungles to escape Cambodia, making it to Thailand alive meant hope.

Thailand looks to the future. The challenges of the past will serve the Thai people well in the coming years. Now that a new era of political stability has returned to Thailand, global investment will no doubt trend upward and you see it in Downtown Bangkok, which is experiencing a renaissance in commercial development. There is a growth of high-tech positions that will have a transformative effect on educated lifestyles. You will also see new opportunities emerge within what used to be the poorer regions of the Thailand, with growth and new development on the forefront.

Thailand now has 18 million people -- out of a population of 65 million -- who use social media regularly. In 1990, roughly a quarter of their population lived below the poverty line. Today the number is just under 10 percent. Health and nutrition among their young have improved. Things are looking up.

There is an urgency to make things happen in Thailand -- a sense that some of the past political disruptions may be a thing of the past. They have moved far beyond the "domino that refused to fall" during the Cold War.

And I look forward to seeing and being a part of their new chapters as they emerge. Oh, by the way, Bloomberg just released its list of top 20 emerging markets; Thailand is #3!

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Follow Mary Buffett on Twitter: www.twitter.com/marybuffett

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Source: http://www.huffingtonpost.com/mary-buffett/reflections-of-a-modern-t_b_3295556.html

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Big Data Analytics Specialist Tableau Software Raises $254M In IPO, Shares Pop 58% In Early Trading

Screen Shot 2013-05-17 at 15.23.04One year to the day of the troubled Facebook IPO, the climate for tech IPOs in the public markets is significantly less stormy, especially for companies in the enterprise space. Today, not one but two are debuting on New York stock exchanges. Business intelligence provider Tableau Software, trading as "DATA", is one of the more highly anticipated tech IPOs of the year, and so far it has not disappointed. It priced its IPO at $31 per share, and it has popped 58% to nearly $49/share in early trading on the NYSE.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/ExGAEU_12fk/

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Obama appoints former Rep. Gabrielle Giffords to Fulbright scholarship board (Star Tribune)

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Friday, May 17, 2013

Study brings greater understanding of tumor growth mechanism

May 16, 2013 ? A study led by researchers from Plymouth University Peninsula Schools of Medicine and Dentistry has for the first time revealed how the loss of a particular tumour suppressing protein leads to the abnormal growth of tumours of the brain and nervous system.

The study is published in Brain: A Journal of Neurology.

Tumour suppressors exist in cells to prevent abnormal cell division in our bodies. The loss of a tumour suppressor called Merlin leads to tumours in many cell types within our nervous systems. There are two copies of a tumour suppressor, one on each chromosome that we inherit from our parents. The loss of Merlin can be caused by random loss of both copies in a single cell, causing sporadic tumours, or by inheriting one abnormal copy and losing the second copy throughout our lifetime as is seen in the inherited condition of neurofibromatosis type 2 (NF2).

With either sporadic loss or inherited NF2, these tumours lacking the Merlin protein develop in the Schwann cells that form the sheaths that surround and electrically insulate neurons. These tumours are called schwannomas, but tumours can also arise in the cells that form the membrane around the brain and spinal cord, and the cells that line the ventricles of the brain.

Although the schwannomas are slow-growing and benign, they are frequent and come in numbers. The sheer number of tumours caused by this gene defect can overwhelm a patient, often leading to hearing loss, disability and eventually death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically manifests in the teenage years and through into adulthood.

No effective therapy for these tumours exists, other than repeated invasive surgery or radiotherapy aiming at a single tumour at a time and which is unlikely to eradicate the full extent of the tumours.

The Brain study investigated how loss of a protein called Sox10 functions in causing these tumours. Sox10 is known to play a major role in the development of Schwann cells, but this is the first time it has been shown to be involved in the growth of schwannoma tumour cells. By understanding the mechanism, the research team has opened the way for new therapies to be developed that will provide a viable to alternative to surgery or radiotherapy.

The study, undertaken by researchers from Plymouth University Peninsula Schools of Medicine and Dentistry with colleagues from the State University of New York and Universitat Erlangen-Nurmberg, was led by Professor David Parkinson.

He said: "We have for the first time shown that human schwannoma cells have reduced expression of Sox10 protein and messenger RNA. By identifying this correlation and gaining an understanding of the mechanism of this process, we hope that drug-based therapies may in time be created and introduced that will reduce or negate the need for multiple surgery or radiotherapy."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/NfZDURML3MQ/130516105515.htm

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Don't let strangers in, even in Paris

When a man in work clothes showed up at her door, the Monitor's Europe bureau chief let him inside. But fortunately, he didn't get a chance to pull off a well-known Parisian scam.

By Sara Miller Llana,?Staff writer / May 17, 2013

People walk in the business district of La D?fense, Paris, Wednesday. The Monitor's Europe bureau chief learns not to let strangers through the front door, even in Paris.

Christophe Ena/AP

Enlarge

I let a stranger into our apartment.

Skip to next paragraph Sara Miller Llana

Europe Bureau Chief

Sara Miller Llana?moved to Paris in April 2013 to become the Monitor's Europe Bureau?Chief. Previously she was the?paper's?Latin America Bureau Chief, based in Mexico City, from 2006 to 2013.

Recent posts

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I suppose that in moving from Mexico City to Paris, and feeling a sudden burst of elation for not having to worry so intently about drug and gang violence and, worst of all kidnapping, I went to the extreme.

A man knocked on the door of our temporary apartment saying he needed to check on something and asked if he could come in. He must have said what he was checking but my French, only now on its way back after lying dormant for over two decades, missed the details. He was dressed in work clothes, and I let him in.

He first said he was looking for the heater panel, then started asking all kinds of questions about who we were and how long we?d been in France. I thought this was a bit bizarre, but didn't think much of it.

Then he spotted the chimney. He opened the screen: ?Oh no, look at all of this soot.? (I had to look up the word for soot, suie, on my laptop.)

?You have a small child,? he went on. ?If she breathes this in, it could be the end. I am obligated to fix this.?

In my daze of jetlag, living out of suitcases, with a mountain of bureaucracy to tackle each day, I actually thought this man might be from the city government, and he was doing his municipal duty, for free, to make sure no Paris residents ? even foreigners, God bless France! ? breathe contaminated air.

I almost let him get to work ? until my more rational husband said, ?Let?s call the owner first.?

The owner's response was immediate: ?Get that guy out of the house now.?

I learned later that it?s a well-known scam in Paris that plumbers or electricians and other workers will come in, and tell you you need X, Y, and Z fixed. A colleague told me one man entered her house, broke a pipe, and then tried to get them to pay to fix it. I told the guardian downstairs about our visitor, and she said any communal or municipal work to be done will always be posted in the building.

Some of these scams are actually done by thieves, she said, who might rob you ? or worse. ?Don?t let anyone in your house. It could be very dangerous.?

I did learn back in elementary school not to talk to strangers, and most definitely not to let them through the front door.

But I had a momentary lapse of judgment, a good reminder that you have to be careful anywhere ? even in Paris!

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/t71YicIf93A/Don-t-let-strangers-in-even-in-Paris

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Same musicians: Brand new tune

Wednesday, May 15, 2013

A small ensemble of musicians can produce an infinite number of melodies, harmonies and rhythms. So too, do a handful of workhorse signaling pathways that interact to construct multiple structures that comprise the vertebrate body. In fact, crosstalk between two of those pathways?those governed by proteins known as Notch and BMP (for Bone Morphogenetic Protein) receptors?occurs over and over in processes as diverse as forming a tooth, sculpting a heart valve and building a brain.

A new study by Stowers Institute for Medical Research Investigator Ting Xie, Ph.D., reveals yet another duet played by Notch and BMP signals, this time with Notch calling the tune. That work, published in this week's online issue of PNAS, uses mouse genetics to demonstrate how one Notch family protein, Notch2, shapes an eye structure known as the ciliary body (CB), most likely by ensuring that BMP signals remain loud and clear.

In vertebrates, the CB encircles the lens and performs two tasks essential for normal vision. First, it contains a tiny muscle that reshapes the lens when you change focus, or "accommodate". And it also secretes liquid aqueous humor into the front compartment of the eye where it likely maintains correct eye pressure. Understanding CB construction is critical, as excessive pressure is one risk factor for glaucoma.

Eye development is a relatively new field for Xie, a recognized leader in the study of adult stem cells in the fruit fly: only recently did he branch out into mouse studies. "A few years ago I was asked to participate in a think tank-type meeting to discuss the potential application of cell therapy to treat glaucoma," he says. "I became interested in using retinal progenitor cells to treat diseases like glaucoma or macular degeneration. But I realized that first we needed to understand eye disease at the molecular level." The new study is an important step in that direction.

Previously, investigators knew that once cells that form the CB are established in an embryo, the BMP pathway drives their "morphogenesis", the term used by developmental biologists to describe the process of expanding and then sculpting a committed population of cells into a unique structure. "The Notch2 receptor was previously shown to be expressed in the developing mouse eye," explains Chris Tanzie, M.D., Ph.D., a former graduate student in the Xie lab and the study's co-first author. "But its function was unknown, and no one connected how various signaling pathways direct CB morphogenesis."

To determine what Notch2 was doing in the developing eye, the Stowers team constructed a conditional knockout mouse, meaning that the Notch2 gene is deleted from the genome only in eye cells that give rise to the CB. In normal newborn mice a series of cellular "folds" that characterize the CB emerges over the first 7 days of life. But the mutant knockout mice showed a complete absence of folds, dramatic evidence that Notch2 is required to elaborate a CB.

Furthermore, in normal mice a protein called Jagged-1, which activates Notch2, was expressed in cells adjacent to Notch2-expressing CB cells during the same developmental period. Strikingly, the team's collaborators in Richard Libby's laboratory at the University of Rochester Medical Center, were able to demonstrate that just like the Notch2 mutants, Jagged-1 conditional knockout mice showed almost total loss of CB fold structures, a major hint that Notch2 was switched on by Jagged1 to drive CB formation.

Biochemical and microarray analysis provided further explanation for defects observed after Notch2 loss. Comparison of normal and Notch2-mutant eye cells revealed that not only did cells of mutant mice lose BMP signaling but that expression of two proteins known to interfere with BMP increased in those cells.

"Up-regulation of BMP antagonists following Notch2 loss is an important observation," says Xie. "In other systems people often observe that Notch and BMP cooperatively regulate common targets by transcription factor collaboration at the transcriptional level, but this is a unique mechanism. We find that Notch2 keeps BMP signaling active by inhibiting its inhibitors."

The study's second co-first author is Yi Zhou, a University of Kansas Medical Center graduate student earning his Ph.D. in Xie's lab. "Our work reveals a novel link between Notch and BMP pathways potentially involved in the pathogenesis of glaucoma," says Zhou, noting one more tantalizing implication of the paper. "In addition, mutations in Jagged-1 and Notch2 are thought to underlie the human genetic disease known as Alagille Syndrome. Our work may lead to a better understanding of both."

Alagille Syndrome is an inherited childhood disorder causing defects in organ systems including liver, heart and the skeleton. Xie is equally intrigued by potential connections between his group's observations in the mouse eye and Alagille outcomes in humans. Nonetheless, he remains focused on nailing down how perturbation of the Jagged1-Notch2-BMP axis might cause eye disease.

"We now know how to build better mouse mutants to study CB development. In this work we show that Notch regulates BMP signaling but have not yet determined whether alterations in CB structure actually change interocular pressure," he says. "Answering that question is our future goal."

###

Stowers Institute for Medical Research: http://www.stowers-institute.org

Thanks to Stowers Institute for Medical Research for this article.

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Source: http://www.labspaces.net/128269/Same_musicians__Brand_new_tune

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