?It?s a really interesting platform because, as a gamer, it?s the first platform that really sort of gives of everything. It?s the first time I can play things like shooters on an aeroplane; and I don?t like feeling I?m playing something that?s compromised in any way.? ? Ken Levine, speaking to PSM3 (via CVG).
Levine announced BioShock Vita at E3 last year, although details remain scarce.
Your W-2 should be hitting your mailbox soon, which means it?s time to start thinking about your tax returns. Yay! Those of you blessed with easy returns now have a new filing option in the way of TurboTax SnapTax for iPhone and camera-equipped iPod Touch.
Sadly for me, my taxes are too complicated to be processed through SnapTax, so I can?t tell you if the filing aspect of the app works flawlessly or not. What I can tell you is that I was impressed with SnapTax?s ability to pull information off of the photo I snapped of my W-2. The app explains how to get the best image of your paperwork, and even though I ignored almost all of the tips, SnapTax still pulled in all information correctly except for the state tax fields. You can opt to type in everything manually, but it?s worth the effort to take the photo and fix the few errors that might occur. SnapTax instantly told me my current refund status for my state and federal returns.
SnapTax is a strict 1040EZ filer, supporting W-2, 1099-INT, 1099-G and 1098-E forms ? anything other than these forms will need to be processed through a different service. After pulling in your information, you?ll be asked to answer a few questions, such as your marital status, job information and if you have dependents. You can start your return without creating an account, but make sure to create one before you leave the app, otherwise SnapTax will clear all of your data for security reasons.
TurboTax SnapTax costs $19.99 to e-file both your federal and state returns, payable through your iTunes account. Before shelling out the cash, though, users might want to see if they?re eligible for free e-filing elsewhere.
Lindsay Lohan has been staying out of trouble lately, and has even been praised by Judge Stephanie Sautner at probation hearings. Dare we say she's turning it around?
Incredibly, it looks like she is. The only allegations she faces these days (save for that tax mishap) are the typical celeb fare - frivolous lawsuits from crazy people.
According to court documents, Thomas A. Green is suing Lohan for $300,000 for "unfair business practices" and allegedly defrauding him in some online business deal.
Green claims he is a former U.S. Marine and says he recently spent time in a homeless shelter due to a "depreciated stage of delusion and hallucinations."
Green believes he began corresponding with Lohan on Facebook on July 18, 2010, and makes references to both public Facebook and Twitter messages that the actress had posted in an effort raise awareness and funds for the disaster in the Gulf Coast.
Green seems to claim was duped by Lohan and when he pressed her about her true intentions, he uncovered a conspiracy about the killing of Osama bin Laden.
He goes on and on and on, but we're just gonna stop right there, because this is going to be thrown out in about two seconds, and we have other things to talk about.
After a full day out around Singapore?we went back to our hotel to freshen up. Then our stomach start to growl again, so we went out for supper at a Food Outlet?in Marine Parade Promenade?near Marine Parade Food Court. This coffee shop is open 24 hours for late night drinkers but the Chu Char (Wok Fried Food)?would close around 11.30 pm. We managed to make the last order for the day and was happilly tucked in the food when we suddenly realised that we need to order more. Too bad, the chu char?owner would not take anymore orders?because they are preparing to close the stall.....sigh...
Although it is about 11.50pm and the?next day is a working day, there is still a good crowd at this eating place. Most of them are here for a nite shot of beer! Yam Seng
The first dish that came, Fried Hor Fun (flat rice noodles) with fish slices and garnished with bean sprouts(taugeh)......very nice.
Fried Ee Mee?(Fried Egg Noodles) which is known as Man Ee Mee in KL. Another tasty dish from this stall.
Ahhhh, I love this Fried Singapore Bihun........ Fried with to perfection! Yum Yum.....
Location :
This makan place (eating place) is very near to the Marine Parade road overhead bridge. If you are crossing the bridge from the opposite site, then walk towards your left. When you see the Marine Parade Promenade Arch, you will notice a corner restaurant with a large 24 Hours sign board. ?
Essential protein for the formation of new blood vessels identifiedPublic release date: 17-Jan-2012 [ | E-mail | Share ]
Contact: Reiner Wimmer reiner.wimmer@univie.ac.at University of Vienna
This release is available in German.
New research explains how cells regulate their bonds during the development of new blood vessels. For the first time, the role of the protein Raf-1 in determining the strength of the bond between cells has been shown. Manuela Baccarini's group at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, shows if Raf-1 is not present, the cells cannot stick together and the formation of new blood vessels is inhibited. This discovery may one day lead to new approaches to cancer treatment.
Angiogenic sprouting, the process by which new blood vessels grow from existing vessels, is a double-edged sword. It enables the cardiovascular system to develop in the embryo, and is vital for tissue regeneration in adults. But it also supplies growing tumors with nutrients and oxygen.
Angiogenesis is an example of collective cellular migration. Cells move as a group, held together by connections called adherens junctions. For the cells to move, they have to make and break these connections continuously. If the junctions are too stiff, they will not be able to move at all, but if they are too weak, the groups of cells will break apart. How this mechanism is controlled was unknown.
The mechanism has now been uncovered by Manuela Baccarini's group at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, who investigate cell signaling. They have established a crucial role for Raf-1, a multi-purpose signal transducer, in this process.
"The real breakthrough came when we were able to use video microscopy on the developing vessels in vitro," explains the paper's first author Reiner Wimmer. "We realized that the cells without Raf-1 were actively migrating, but only as single cells. They could not migrate in a group."
The meaning of this discovery became clear in further experiments: the role of Raf-1 is to bring the new adherens junctions a kinase they need for the remodeling of the cytoskeleton. This means that Raf-1 is fine-tuning the bonds between the migrating cells by causing the local remodeling of the cell's cytoskeleton.
As the process of angiogenic sprouting is necessary for the growth of tumors, this new discovery may one day be applied to produce cancer therapies to target Raf-1 and the other parts of this control mechanism, thereby disrupting the environment of the tumor.
###
Publication
Wimmer R, Cseh B, Maier B, Scherrer K, Baccarini M (2011). Angiogenic sprouting requires the fine-tuning of endothelial cell cohesion by the Raf-1/Rok-? complex. Developmental Cell.
DOI 10.1016/j.devcel.2011.11.012
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Essential protein for the formation of new blood vessels identifiedPublic release date: 17-Jan-2012 [ | E-mail | Share ]
Contact: Reiner Wimmer reiner.wimmer@univie.ac.at University of Vienna
This release is available in German.
New research explains how cells regulate their bonds during the development of new blood vessels. For the first time, the role of the protein Raf-1 in determining the strength of the bond between cells has been shown. Manuela Baccarini's group at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, shows if Raf-1 is not present, the cells cannot stick together and the formation of new blood vessels is inhibited. This discovery may one day lead to new approaches to cancer treatment.
Angiogenic sprouting, the process by which new blood vessels grow from existing vessels, is a double-edged sword. It enables the cardiovascular system to develop in the embryo, and is vital for tissue regeneration in adults. But it also supplies growing tumors with nutrients and oxygen.
Angiogenesis is an example of collective cellular migration. Cells move as a group, held together by connections called adherens junctions. For the cells to move, they have to make and break these connections continuously. If the junctions are too stiff, they will not be able to move at all, but if they are too weak, the groups of cells will break apart. How this mechanism is controlled was unknown.
The mechanism has now been uncovered by Manuela Baccarini's group at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, who investigate cell signaling. They have established a crucial role for Raf-1, a multi-purpose signal transducer, in this process.
"The real breakthrough came when we were able to use video microscopy on the developing vessels in vitro," explains the paper's first author Reiner Wimmer. "We realized that the cells without Raf-1 were actively migrating, but only as single cells. They could not migrate in a group."
The meaning of this discovery became clear in further experiments: the role of Raf-1 is to bring the new adherens junctions a kinase they need for the remodeling of the cytoskeleton. This means that Raf-1 is fine-tuning the bonds between the migrating cells by causing the local remodeling of the cell's cytoskeleton.
As the process of angiogenic sprouting is necessary for the growth of tumors, this new discovery may one day be applied to produce cancer therapies to target Raf-1 and the other parts of this control mechanism, thereby disrupting the environment of the tumor.
###
Publication
Wimmer R, Cseh B, Maier B, Scherrer K, Baccarini M (2011). Angiogenic sprouting requires the fine-tuning of endothelial cell cohesion by the Raf-1/Rok-? complex. Developmental Cell.
DOI 10.1016/j.devcel.2011.11.012
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 17-Jan-2012
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